Everyone has their favorites but here's what I experienced in my 36 years of trucking. I had started using Power Service in my C13 and C15 Cat's. We have good fuel up here and have never had a water issue, but in 05 when all this emission stuff started to get going I decided to use it just for the extra lubricity with these new high injection pressures.
Then I got into hauling RV trailers for a two years when trucking got bad around 2008, with my Superduty Powerstroke. I was running Power Service in it. One day while running across Coldwater Michigan on my way to Indiana to pick up a trailer my check engine light came on and my 6.0 PS started running like....well, a P.O.S. LOL
I went to a Ford dealer and they said two injectors died. But they were too busy to get me in so they said I would make it home but it would run rough and fuel mileage would suffer.
So I had to get fuel and figured I'd put more conditioner in. The fuel stop did not have Power Service but they had Howes which I knew nothing about. I put it in and within ten minutes on the freeway truck started running perfect again. It unstuck the injectors.
Not a scientific test, but enough it had me sold from then on. I even put it in my furnace oil tank. I have used it in all my tractors from new.
So that's all I know.....2 injectors stuck with Power Service in my fuel and Howes unstuck them.
Only other brand I tried was Caterpillar. My Cat shop guy gave me a bottle once and he said "I'm like a drug dealer because once you try this you won't stop" Well I did stop because it wasn't cheap but in my big Cat's I could actually feel an increase in power and throttle response.